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Article

Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma.

Journal of cancer research and clinical oncology - 1 May 2009

Borkosky Silvia S, Gunduz Mehmet, Nagatsuka Hitoshi, Beder Levent Bekir, Gunduz Esra, Ali Mahmoud A L Sheikh, Rodriguez Andrea P, Cilek Mehmet Zeynel, Tominaga Susumu, Yamanaka Noboru, Shimizu Kenji, Nagai Noriyuki

Abstract excerpt

BACKGROUND: Loss of heterozygosity (LOH) in the ING family members has been shown in head and neck squamous cell carcinoma (HNSCC) except for ING2. Like all the other members of ING family, ING2, which is located at chromosome 4q35.1, is a promising tumor suppressor gene (TSG). In this study, we performed LOH analysis of ING2 in HNSCC and compared it with clinicopathological variables. MATERIALS AND METHODS: We...

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Share to Carcinoma, Squamous Cell
Share to Chromosomes, Human, Pair 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Head and Neck Neoplasms

Share to Loss of Heterozygosity

Share to Receptors, Cytoplasmic and Nuclear

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Source

Identifiers

PMID: 18998165
DOI: 10.1007/s00432-008-0507-y

Genes

ING2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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