Article
Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer.
Oncology reports - 1 Mar 2006
Okano Tetsuya, Gemma Akihiko, Hosoya Yoko, Hosomi Yukio, Nara Michiya, Kokubo Yutaka, Yoshimura Akinobu, Shibuya Masahiko, Nagashima Makoto, Harris Curtis C, Kudoh Shoji
Abstract excerpt
The ING1 gene is involved in the regulation of the cell cycle, senescence, and apoptosis and is a novel candidate tumor suppressor gene. ING2, another gene in the ING family, was identified and cloned. The functions of ING1 and ING2 largely depend on the activity of p53. To determine whether an alteration in these genes plays a role in carcinogenesis and tumor progression in lung cancer, we screened 30 human lung...
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