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Article

Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas.

Gene - 15 Aug 2005

Gunduz Mehmet, Nagatsuka Hitoshi, Demircan Kadir, Gunduz Esra, Cengiz Beyhan, Ouchida Mamoru, Tsujigiwa Hidetsugu, Yamachika Eiki, Fukushima Kunihiro, Beder Levent, Hirohata Satoshi, Ninomiya Yoshifumi, Nishizaki Kazunori, Shimizu Kenji, Nagai Noriyuki

Abstract excerpt

We previously showed two members of the ING family, ING1 and ING3 as a tumor suppressor gene in head and neck cancer. Progress in human genome sequencing provided additional information of the new members of the ING family genes. ING4 is localized to chromosome 12p13.31 region and harbors the PHD domain highly homologous among ING family proteins. We analyzed loss of heterozygosity at 12p12-13 region in 50 head...

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Share to Carcinoma, Squamous Cell
Share to Chromosomes, Human, Pair 12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Head and Neck Neoplasms

Share to Loss of Heterozygosity

Share to Physical Chromosome Mapping

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Source

Identifiers

PMID: 15935570
DOI: 10.1016/j.gene.2005.02.014

Genes

ING4
ING1
ING3

Provenance

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