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Article

beta-Catenin stabilization imparts crypt progenitor phenotype to hyperproliferating colonic epithelia.

Experimental cell research - 1 Jan 2009

Sellin Joseph H, Wang Yu, Singh Pomila, Umar Shahid

Abstract excerpt

Utilizing the Citrobacter rodentium (CR)-induced transmissible murine colonic hyperplasia (TMCH) model, we provide mechanistic basis of changes in beta-catenin/APC/CKIepsilon leading to progression and/or regression of hyperplasia in vivo. In response to CR-induced TMCH, crypt lengths increased significantly between days 6-27 post-infection, followed by a steep decline by day 34. beta-Cat(45)/total beta-catenin...

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Identifiers

PMID: 18996369
DOI: 10.1016/j.yexcr.2008.10.019
PMCID: PMC2868370

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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