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Article

K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia.

Cancer research - 1 Nov 2010

Okumura Tomoyuki, Ericksen Russell E, Takaishi Shigeo, Wang Sophie S W, Dubeykovskiy Zinaida, Shibata Wataru, Betz Kelly S, Muthupalani Sureshkuma, Rogers Arlin B, Fox James G, Rustgi Anil K, Wang Timothy C

Abstract excerpt

Chronic infectious diseases, such as Helicobacter pylori infection, can promote cancer in a large part through induction of chronic inflammation. Oncogenic K-ras mutation in epithelial cells activates inflammatory pathways, which could compensate for a lack of infectious stimulus. Gastric histopa...

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Identifiers

PMID: 20959488
DOI: 10.1158/0008-5472.CAN-10-1506
PMCID: PMC2970750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20959488-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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