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Article

Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection.

Gastroenterology - 1 Apr 2008

McConnell Beth B, Klapproth Jan-Michael A, Sasaki Maiko, Nandan Mandayam O, Yang Vincent W

Abstract excerpt

BACKGROUND & AIMS: Krüppel-like factor 5 (KLF5) is a transcription factor that is highly expressed in proliferating crypt cells of the intestinal epithelium. KLF5 has a pro-proliferative effect in vitro and is induced by mitogenic and stress stimuli. To determine whether KLF5 is involved in mediating proliferative responses to intestinal stressors in vivo, we examined its function in a mouse model of...

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Source

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Identifiers

PMID: 18395082
DOI: 10.1053/j.gastro.2008.01.013
PMCID: PMC2336106

Genes

KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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