Article
E-cadherin can limit the transforming properties of activating β-catenin mutations.
The EMBO journal - 14 Sept 2015
Huels David J, Ridgway Rachel A, Radulescu Sorina, Leushacke Marc, Campbell Andrew D, Biswas Sujata, Leedham Simon, Serra Stefano, Chetty Runjan, Moreaux Guenievre, Parry Lee, Matthews James, Song Fei, Hedley Ann, Kalna Gabriela, Ceteci Fatih, Reed Karen R, Meniel Valerie S, Maguire Aoife, Doyle Brendan, Söderberg Ola, Barker Nick, Watson Alastair, Larue Lionel, Clarke Alan R, Sansom Owen J
Abstract excerpt
Wnt pathway deregulation is a common characteristic of many cancers. Only colorectal cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of the pancreas) have activating mutations in β-catenin (CTNNB1). We have compared the dynamics and the potency of β-catenin mutations in vivo. Within the murine small intestine (SI), an activating...
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