Article
A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.
Disease models & mechanisms - 1 Nov 2015
Buchert Michael, Rohde Franziska, Eissmann Moritz, Tebbutt Niall, Williams Ben, Tan Chin Wee, Owen Alexander, Hirokawa Yumiko, Gnann Alexandra, Orend Gertraud, Orner Gayle, Dashwood Rod H, Heath Joan K, Ernst Matthias, Janssen Klaus-Peter
Abstract excerpt
Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great extent by the genetic make-up of individual tumors and the combination of oncogenic mutations. In order to express throughout the intestinal epithelium a...
Topics
- Adenomatous Polyps
- Animals
- Azoxymethane
- Cell Transformation, Neoplastic
- Colitis
- Colon
- Colonic Neoplasms
- Colonic Polyps
- Cytokines
- Gene Expression Regulation, Neoplastic