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Article

Mechanisms of cAMP-mediated gene induction: examination of renal epithelial cell mutants affected in the catalytic subunit of the cAMP-dependent protein kinase.

Experimental cell research - 1 Jan 1991

Pearson D, Nigg E A, Nagamine Y, Jans D A, Hemmings B A

Abstract excerpt

The precise mechanistic role of the cAMP-dependent protein kinase (cAMP-PK) in cAMP-mediated gene induction remains unclear. Renal epithelial cell mutants were compared to the LLC-PK1 parental cell line for induction of the cAMP-responsive urokinase-type plasminogen activator (uPA) gene, as quantitated by the technique of mRNA solution hybridization. The FIB4 and FIB6 mutants, which possess less than 10% parental...

Topics

Animals
Biological Transport
Cell Line
Epithelial Cells
Epithelium
Gene Expression Regulation
Immunohistochemistry
Kidney
Mutation
Plasminogen Activators
Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Subcellular Fractions

Tetradecanoylphorbol Acetate

Transcriptional Activation

Urokinase-Type Plasminogen Activator

Source

Identifiers

PMID: 1898592
DOI: 10.1016/0014-4827(91)90193-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1898592-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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