Characterization of a cAMP-dependent protein kinase mutant resistant to cisplatin.

doi:10.1002/(sici)1097-0215(19970717)72:2<345::aid-ijc24>3.0.co;2-d

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Article

Characterization of a cAMP-dependent protein kinase mutant resistant to cisplatin.

International journal of cancer - 17 Jul 1997

Cvijic M E, Chin K V

Abstract excerpt

The signal transduction pathway of cAMP, mediated by the cAMP-dependent protein kinase (PKA), is involved in the regulation of metabolisms, cell growth and differentiation and gene expression. Isolated PKA mutants from Chinese hamster ovary (CHO) cells were used in our laboratory to study the rol...

Topics

Animals
Antineoplastic Agents
CHO Cells
Cisplatin
Cricetinae
Cyclic AMP-Dependent Protein Kinases
Drug Resistance, Neoplasm
Mutation
Signal Transduction

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