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Article

Characterization of a cAMP-dependent protein kinase mutant resistant to cisplatin.

International journal of cancer - 17 Jul 1997

Cvijic M E, Chin K V

Abstract excerpt

The signal transduction pathway of cAMP, mediated by the cAMP-dependent protein kinase (PKA), is involved in the regulation of metabolisms, cell growth and differentiation and gene expression. Isolated PKA mutants from Chinese hamster ovary (CHO) cells were used in our laboratory to study the role of cAMP in the development of drug resistance in cancer. We have found that PKA mutants harboring a defective...

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Identifiers

PMID: 9219844
DOI: 10.1002/(sici)1097-0215(19970717)72:2<345::aid-ijc24>3.0.co;2-d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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