Article
Inhibition of cell differentiation by G alpha q in the renal epithelial cell line LLC-PK1.
The American journal of physiology - 1 Apr 1998
Sun L, Weaver D J, Amsler K, Weiss E R
Abstract excerpt
LLC-PK1, an epithelial cell line derived from the kidney proximal tubule, was used to study the ability of the G protein alpha-subunit, G alpha q, to regulate cell differentiation. A constitutively active mutant protein, alpha qQ209L, was expressed using the LacSwitch-inducible mammalian expressi...
Topics
- Alkaline Phosphatase
- Animals
- Biological Transport
- Cell Differentiation
- Enzyme Activation
- Enzyme Inhibitors
- Epithelial Cells
- GTP-Binding Proteins
- Hexoses
- Kidney
- LLC-PK1 Cells
- Mutation
- Protein Kinase C
- Sodium
- Swine
- Type C Phospholipases