Article
Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1997
Cvijic M E, Chin K V
Abstract excerpt
Multidrug resistance (MDR) in cancer poses a major obstacle to the success of chemotherapy. We previously reported that cyclic AMP (cAMP)-resistant mutants of the Chinese hamster ovary and the mouse adrenal cortical carcinoma cells harboring defective regulatory (RI alpha) subunits of the cAMP-de...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents
- Blotting, Western
- CHO Cells
- Carrier Proteins
- Cell Cycle
- Cricetinae
- Cyclic AMP-Dependent Protein Kinases
- Drug Resistance, Neoplasm
- Flow Cytometry
- Humans
- Intracellular Signaling Peptides and Proteins
- KB Cells
- Mutation
- Protein Kinases