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Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1997

Cvijic M E, Chin K V

Abstract excerpt

Multidrug resistance (MDR) in cancer poses a major obstacle to the success of chemotherapy. We previously reported that cyclic AMP (cAMP)-resistant mutants of the Chinese hamster ovary and the mouse adrenal cortical carcinoma cells harboring defective regulatory (RI alpha) subunits of the cAMP-dependent protein kinase (PKA) are more sensitive than wild-type cells to chemotherapeutic agents that are substrates for...

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PMID: 9419412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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