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Article

A novel LLC-PK1 renal epithelial cell mutant impaired in in vivo down-regulation of cAMP-mediated hormonal response.

Archives of biochemistry and biophysics - 1 Mar 1991

Jans D A, Resink T J, Hemmings B A

Abstract excerpt

A novel "cAMP-resistant" variant of LLC-PK1 renal epithelial cells which is impaired in in vivo down-regulation of response following hormonal stimulation of adenylate cyclase (AC) is described. Compared to parental cells, the BIB27 mutant exhibited markedly higher in vivo activation of cAMP-dependent protein kinase (cAMP-PK) in response to the hormones salmon calcitonin (SCT) or [Arg8]-vasopressin (AVP) or the...

Topics

1-Methyl-3-isobutylxanthine
Adenylyl Cyclases
Animals
Arginine Vasopressin
Calcitonin
Cell Line
Colforsin
Cyclic AMP
Drug Resistance
Enzyme Activation
Epithelium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Guanylyl Imidodiphosphate

Kidney

Mutation

Protein Kinases

Swine

Source

Identifiers

PMID: 1716864
DOI: 10.1016/0003-9861(91)90376-t

Genes

AVP
SCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1716864-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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