Article
Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct.
American journal of physiology. Cell physiology - 1 Nov 2015
Blount Mitsi A, Cipriani Penelope, Redd Sara K, Ordas Ronald J, Black Lauren N, Gumina Diane L, Hoban Carol A, Klein Janet D, Sands Jeff M
Abstract excerpt
Hypertonicity increases urea transport, as well as the phosphorylation and membrane accumulation of UT-A1, the transporter responsible for urea permeability in the inner medullary collect duct (IMCD). Hypertonicity stimulates urea transport through PKC-mediated phosphorylation. To determine whether PKC phosphorylates UT-A1, eight potential PKC phosphorylation sites were individually replaced with alanine and...
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