Specific inhibition of protein kinase A in granulosa cells abolishes gonadotropin regulation of the proopiomelanocortin promoter.

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Article

Specific inhibition of protein kinase A in granulosa cells abolishes gonadotropin regulation of the proopiomelanocortin promoter.

The Journal of biological chemistry - 25 Aug 1991

Young S L, Searles R P, Kaynard A H, Melner M H

Abstract excerpt

Gonadotropins (follicle-stimulating hormone (FSH), luteinizing hormone, and human chorionic gonadotropin) and beta-adrenergic agonists have been shown to stimulate expression of the proopiomelanocortin (POMC) gene in ovarian granulosa cells. The current studies investigate the intracellular mechanisms by which gonadotropins regulate gene expression. Primary cultures of rat granulosa cells were transfected with...

Topics

Animals
Base Sequence
Chloramphenicol O-Acetyltransferase
DNA
Female
Follicle Stimulating Hormone
Gene Expression Regulation, Enzymologic
Gonadotropins
Granulosa Cells
Isoproterenol
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pro-Opiomelanocortin

Promoter Regions, Genetic

Protein Kinase Inhibitors

Rats

TATA Box

Transfection

Source

Open in PubMed

Identifiers

PMID: 1908460

Genes

POMC
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1908460-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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