Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children.

Inflammatory bowel diseases - 1 Apr 2009

Amre Devendra K, Mack David R, Morgan Kenneth, Krupoves Alfreda, Costea Irina, Lambrette Philippe, Grimard Guy, Dong Jinsong, Feguery Houda, Bucionis Vytautas, Deslandres Colette, Levy Emile, Seidman Ernest G

Abstract excerpt

BACKGROUND: Recent genome-wide studies have implicated the autophagy genes ATG16L1 and IRGM in the pathogenesis of Crohn's disease (CD). We investigated whether these genes were associated with CD in Canadian children. METHODS: A case-control study was carried out at 2 pediatric gastroenterology clinics in Canada. Confirmed cases of CD <20 years diagnosed using standard criteria were classified according to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nod2 Signaling Adaptor Protein
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy-Related Proteins

Share to Canada

Share to Carrier Proteins

Share to Case-Control Studies

Share to Crohn Disease

Share to GTP-Binding Proteins

Source

Identifiers

PMID: 18985712
DOI: 10.1002/ibd.20785

Genes

IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children.PMID 18985712Read ↗

Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children.Semantic proximity Read ↗

Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe.Semantic proximity Read ↗

Functional consequences of mutations in the autophagy genes in the pathogenesis of Crohn's disease.Semantic proximity Read ↗

Genome-wide Association Scanning Highlights Two Autophagy Genes,<i>ATG16L1</i>and<i>IRGM</i>, as Being Significantly Associated with Crohn’s DiseaseSemantic proximity Read ↗

Among autophagy genes, ATG16L1 but not IRGM is associated with Crohn's disease in Iranians.Semantic proximity Read ↗

Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene.Semantic proximity Read ↗

Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease.Semantic proximity Read ↗

Role of autophagy and autophagy genes in inflammatory bowel disease.Semantic proximity Read ↗

IRGM variants and susceptibility to inflammatory bowel disease in the German population.Semantic proximity Read ↗

A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.Semantic proximity Read ↗

The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.Semantic proximity Read ↗

Autophagy and Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.