Article
Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe.
Inflammatory bowel diseases - 1 Mar 2008
Van Limbergen J, Russell R K, Nimmo E R, Drummond H E, Smith L, Anderson N H, Davies G, Gillett P M, McGrogan P, Weaver L T, Bisset W M, Mahdi G, Arnott I D, Wilson D C, Satsangi J
Abstract excerpt
BACKGROUND: The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults. Our aim was to assess whether germline variation of ATG16L1 acts as an independent determinant of susceptibility to childhood-onset CD in the high-incidence Scottish population. METHODS: In all, 2195 subjects (361 children (inflammatory bowel disease [IBD] diagnosis <17 years),...
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