Article
Genetic variations of the SLC22A5 gene in the Chinese and Indian populations of Singapore.
Drug metabolism and pharmacokinetics - 1 Jan 2010
Toh Dorothy Su Lin, Yee Jie Yin, Koo Seok Hwee, Murray Michael, Lee Edmund Jon Deoon
Abstract excerpt
Novel organic cation transporter 2 (OCTN2) is a multispecific, bidirectional, pH-dependent organic cation transporter. It can function as a carnitine co-transporter with higher affinity for carnitine than OCTN1 but also functions as a uniporter for other cations. Drugs such as verapamil, pyrilamine and beta-lactam antibiotics have been characterized as substrates of OCTN2 and/or inhibitors of carnitine transport....
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