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Pharmacogenetics of CYP1A2, novel polymorphisms and haplotypes in three distinct Asian populations.

Drug metabolism and pharmacokinetics - 1 Jan 2010

Lim Joanne Siok Liu, Singh Onkar, Ramasamy Rathi Devi, Ramasamy Saminathan, Subramanian Koilan, Lee Edmund J D, Chowbay Balram

Abstract excerpt

CYP1A2 play an important role in the metabolism of many carcinogens and clinically important drugs. CYP1A2 activity has been found to be influenced by the presence of polymorphic variants which were reported to display wide interethnic variation. This study investigates the frequency distribution and linkage disequilibrium patterns of CYP1A2 genetic polymorphisms, and characterize their haplotype structures in...

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PMID: 20930417
DOI: 10.2133/dmpk.dmpk-10-sc-051

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