Genotype error detection using Hidden Markov Models of haplotype diversity.

doi:10.1089/cmb.2007.0133

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Article

Genotype error detection using Hidden Markov Models of haplotype diversity.

Journal of computational biology : a journal of computational molecular cell biology - 1 Nov 2008

Kennedy Justin, Măndoiu Ion, Paşaniuc Bogdan

Abstract excerpt

The presence of genotyping errors can invalidate statistical tests for linkage and disease association, particularly for methods based on haplotype analysis. Becker et al. have recently proposed a simple likelihood ratio approach for detecting errors in trio genotype data. Under this approach, a...

Topics

Algorithms
Computer Simulation
Genetic Linkage
Genetic Variation
Genotype
Haplotypes
Humans
Likelihood Functions
Markov Chains
Models, Genetic

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