Article
Error detection for genetic data, using likelihood methods.
American journal of human genetics - 1 Jan 1996
Ehm M G, Kimmel M, Cottingham R W
Abstract excerpt
As genetic maps become denser, the effect of laboratory typing errors becomes more serious. We review a general method for detecting errors in pedigree genotyping data that is a variant of the likelihood-ratio test statistic. It pinpoints individuals and loci with relatively unlikely genotypes. Power and significance studies using Monte Carlo methods are shown by using simulated data with pedigree structures...
Topics
- Cardiomyopathy, Dilated
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Computer Simulation
- False Positive Reactions
- Female
- Genetic Linkage
- Genotype
- Humans
- Male
- Mathematics
- Models, Genetic