Article

ROHMM -- A Flexible Hidden Markov Model Framework To Detect Runs of Homozygosity From Genotyping Data

2021-09-25

Abstract excerpt

Runs of long homozygous stretches (ROH) are considered to be the result of consanguinity and usually contain recessive deleterious disease causing mutations (Szpiech et al., 2013). Several algorithms have been developed to detect ROHs. Here, we developed a simple, alternative strategy by examining X chromosome non-pseudoautosomal region to detect the ROHs from next generation sequencing data utilizing the genotype...

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Literature Corpus work: 8125a340-17ef-5169-90f5-8583290f8d23
DOI: 10.22541/au.163254594.45276658/v1

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