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Article

A block-free hidden Markov model for genotypes and its application to disease association.

Journal of computational biology : a journal of computational molecular cell biology - 1 Dec 2005

Kimmel Gad, Shamir Ron

Abstract excerpt

We present a new stochastic model for genotype generation. The model offers a compromise between rigid block structure and no structure altogether: It reflects a general blocky structure of haplotypes, but also allows for "exchange" of haplotypes at nonboundary SNP sites; it also accommodates rare haplotypes and mutations. We use a hidden Markov model and infer its parameters by an expectation-maximization...

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Identifiers

PMID: 16379532
DOI: 10.1089/cmb.2005.12.1243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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