Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.

Journal of diabetes research - 1 Jan 2016

Babad Jeffrey, Ali Riyasat, Schloss Jennifer, DiLorenzo Teresa P

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. Multiple genetic loci contribute to disease susceptibility in humans, with the most responsible locus being the major histocompatibility complex (MHC). Certain MHC alleles are predisposing, including the common HLA-A(∗)02:01. After the MHC, the locus conferring the strongest...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta 2-Microglobulin
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down-Regulation

Share to HLA-A2 Antigen

Share to Insulin

Share to Islets of Langerhans

Share to Mice, Inbred NOD

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 26824049
DOI: 10.1155/2016/7959060
PMCID: PMC4707332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.PMID 26824049Read ↗

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression.Semantic proximity Read ↗

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression <sup>1</sup>Semantic proximity Read ↗

Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.Semantic proximity Read ↗

Understanding autoimmune diabetes: insights from mouse models.Semantic proximity Read ↗

Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes.Semantic proximity Read ↗

Type 1 diabetes: lessons for other autoimmune diseases?Semantic proximity Read ↗

HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic MiceSemantic proximity Read ↗

Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment.Semantic proximity Read ↗

Lessons on autoimmune diabetes from animal models.Semantic proximity Read ↗

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.Semantic proximity Read ↗

The targeting of β-cells by T lymphocytes in human type 1 diabetes: clinical perspectives.Semantic proximity Read ↗

THE NOD MOUSE: A Model of Immune DysregulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.