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Article

Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2006

Chaparro Rodolfo José, Konigshofer Yves, Beilhack Georg F, Shizuru Judith A, McDevitt Hugh O, Chien Yueh-Hsiu

Abstract excerpt

Before the onset of autoimmune destruction, type 1 diabetic patients and an animal model, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration. To better understand these abnormalities, but without the complications associated with lymphocytic infiltrates, we examined genes expressed in autoimmune target...

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Identifiers

PMID: 16895987
DOI: 10.1073/pnas.0604317103
PMCID: PMC1832259

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