Article
Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1.
Nature - 19 Sept 1991
Cornall R J, Prins J B, Todd J A, Pressey A, DeLarato N H, Wicker L S, Peterson L B
Abstract excerpt
Human type 1 (insulin-dependent) diabetes is a common auto-immune disease of the insulin-producing beta cells of the pancreas which is caused by both genetic and environmental factors. Several features of the genetics and immunopathology of diabetes in nonobese diabetic (NOD) mice are shared with...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Cyclophosphamide
- DNA
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Type 1
- Genetic Linkage
- Genotype
- Humans
- Interleukin-1
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Receptors, Immunologic
- Receptors, Interleukin-1