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Article

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1.

Nature - 19 Sept 1991

Cornall R J, Prins J B, Todd J A, Pressey A, DeLarato N H, Wicker L S, Peterson L B

Abstract excerpt

Human type 1 (insulin-dependent) diabetes is a common auto-immune disease of the insulin-producing beta cells of the pancreas which is caused by both genetic and environmental factors. Several features of the genetics and immunopathology of diabetes in nonobese diabetic (NOD) mice are shared with the human disease. Of the three diabetes-susceptibility genes, Idd-1 -3 and -4 that have been mapped in mice to date,...

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PMID: 1832743
DOI: 10.1038/353262a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1.PMID 1832743Read ↗

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Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.Semantic proximity Read ↗

Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.Semantic proximity Read ↗

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.Semantic proximity Read ↗

Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.Semantic proximity Read ↗

The targeting of β-cells by T lymphocytes in human type 1 diabetes: clinical perspectives.Semantic proximity Read ↗

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.Semantic proximity Read ↗

Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat).Semantic proximity Read ↗

Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1.Semantic proximity Read ↗

The non-obese diabetic mouse sequence, annotation and variation resource: an aid for investigating type 1 diabetes.Semantic proximity Read ↗

Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.Semantic proximity Read ↗

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