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Article

A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.

The Journal of clinical investigation - 15 Oct 1997

Yokoi N, Kanazawa M, Kitada K, Tanaka A, Kanazawa Y, Suda S, Ito H, Serikawa T, Komeda K

Abstract excerpt

The Long-Evans Tokushima Lean (LETL) rat, characterized by rapid onset of insulin-dependent (type I) diabetes mellitus (IDDM), no sex difference in the incidence of IDDM, autoimmune destruction of pancreatic beta cells, and no significant T cell lymphopenia, is a desirable animal model for human IDDM. We have established a diabetes-prone substrain of the LETL rat, named Komeda Diabetes-Prone (KDP) rat, showing a...

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Identifiers

PMID: 9329965
DOI: 10.1172/JCI119733
PMCID: PMC508391

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