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Article

Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2014

Zhao Yan, Yang Xiaoer, Hao Xiaojiao, Pan Xiaolin, Zhao Bo, Ma Jingwen, Fang Jian, Zhao Minghong

Abstract excerpt

Due to its important biological function as a key negative regulator of p53, the mouse double minute 2 homologue (MDM2) gene has been extensively studied. A functional variant in the MDM2 gene promoter, single-nucleotide polymorphism 309 (SNP309) T > G (rs2279744), has been reported to cause an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity, which may be associated with the...

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Identifiers

PMID: 24792886
DOI: 10.1007/s13277-014-1886-0

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies.PMID 24792886Read ↗

MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

Relationship Between Murine Double Minute 2 (MDM2) T309G Polymorphism and Endometrial Cancer Risk: A Meta-Analysis.Semantic proximity Read ↗

MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 is associated with endometrial cancer risk.Semantic proximity Read ↗

Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer.Semantic proximity Read ↗

The association between murine double minute 2 (MDM2) rs2279744 and endometrial cancer risk in a Chinese Han population.Semantic proximity Read ↗

Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk.Semantic proximity Read ↗

An updated meta-analysis on the association of MDM2 SNP309 polymorphism with colorectal cancer risk.Semantic proximity Read ↗

Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk.Semantic proximity Read ↗

MDM2 SNP309 variation increases cervical cancer risk among Asians.Semantic proximity Read ↗

MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 polymorphism is associated with colorectal cancer risk.Semantic proximity Read ↗

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