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Article

Probing general base catalysis in the hammerhead ribozyme.

Journal of the American Chemical Society - 19 Nov 2008

Thomas Jason M, Perrin David M

Abstract excerpt

Recent structural and computational studies have shed new light on the catalytic mechanism and active site structure of the RNA cleaving hammerhead ribozyme. Consequently, specific ribozyme functional groups have been hypothesized to be directly involved in general/acid base catalysis. In order to test this hypothesis, we have developed an affinity label to identify the functional general base in the S. mansoni...

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Identifiers

PMID: 18950173
DOI: 10.1021/ja804496z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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