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Article

Identification of hammerhead ribozymes in all domains of life reveals novel structural variations.

PLoS computational biology - 1 May 2011

Perreault Jonathan, Weinberg Zasha, Roth Adam, Popescu Olivia, Chartrand Pascal, Ferbeyre Gerardo, Breaker Ronald R

Abstract excerpt

Hammerhead ribozymes are small self-cleaving RNAs that promote strand scission by internal phosphoester transfer. Comparative sequence analysis was used to identify numerous additional representatives of this ribozyme class than were previously known, including the first representatives in fungi and archaea. Moreover, we have uncovered the first natural examples of "type II" hammerheads, and our findings reveal...

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PMID: 21573207
DOI: 10.1371/journal.pcbi.1002031
PMCID: PMC3088659

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