Article
The ubiquitous hammerhead ribozyme.
RNA (New York, N.Y.) - 1 May 2012
Hammann Christian, Luptak Andrej, Perreault Jonathan, de la Peña Marcos
Abstract excerpt
The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-) cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three helices, two of which form essential tertiary interactions for fast self-scission under physiological conditions. Originally discovered in subviral plant pathogens, its presence in several eukaryotic genomes has been reported since. More...
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