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Article

Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme.

Nature chemistry - 1 Feb 2020

Ganguly Abir, Weissman Benjamin P, Giese Timothy J, Li Nan-Sheng, Hoshika Shuichi, Rao Saieesh, Benner Steven A, Piccirilli Joseph A, York Darrin M

Abstract excerpt

The Varkud satellite ribozyme catalyses site-specific RNA cleavage and ligation, and serves as an important model system to understand RNA catalysis. Here, we combine stereospecific phosphorothioate substitution, precision nucleobase mutation and linear free-energy relationship measurements with molecular dynamics, molecular solvation theory and ab initio quantum mechanical/molecular mechanical free-energy...

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Identifiers

PMID: 31959957
DOI: 10.1038/s41557-019-0391-x
PMCID: PMC7389185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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