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Article

Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.

PloS one - 1 Jan 2008

Busuttil Rita A, Muñoz Denise P, Garcia Ana Maria, Rodier Francis, Kim Woo Ho, Suh Yousin, Hasty Paul, Campisi Judith, Vijg Jan

Abstract excerpt

Non-homologous end joining (NHEJ) is thought to be an important mechanism for preventing the adverse effects of DNA double strand breaks (DSBs) and its absence has been associated with premature aging. To investigate the effect of inactivated NHEJ on spontaneous mutation frequencies and spectra in vivo and in cultured cells, we crossed a Ku80-deficient mouse with mice harboring a lacZ-plasmid-based mutation...

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Source

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Identifiers

PMID: 18941635
DOI: 10.1371/journal.pone.0003458
PMCID: PMC2565499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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