Article
Aging and genome maintenance.
Annals of the New York Academy of Sciences - 1 Dec 2005
Vijg Jan, Busuttil Rita A, Bahar Rumana, Dollé Martijn E T
Abstract excerpt
Genomic instability in somatic cells has been implicated as a major stochastic mechanism of aging. Using a transgenic mouse model with chromosomally integrated lacZ mutational target genes, we found mutations to accumulate with age at an organ- and tissue-specific rate. Also the spectrum of age-accumulated mutations was found to differ greatly from organ to organ; while initially similar, mutation spectra of...
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