Article
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
Nature genetics - 1 Dec 1997
Dollé M E, Giese H, Hopkins C L, Martus H J, Hausdorff J M, Vijg J
Abstract excerpt
Somatic mutations have long been considered a possible cause of ageing. To directly study mutational events in organs and tissues of ageing mammals, a transgenic mouse model has been generated that harbours lacZ reporter genes as part of chromosomally integrated plasmids. Using this model, we det...
Topics
- Aging
- Animals
- Brain
- DNA Mutational Analysis
- Gene Rearrangement
- Genome
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Organ Specificity
- Oxidative Stress
- Recombination, Genetic