Article
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
Nature genetics - 1 Dec 1997
Dollé M E, Giese H, Hopkins C L, Martus H J, Hausdorff J M, Vijg J
Abstract excerpt
Somatic mutations have long been considered a possible cause of ageing. To directly study mutational events in organs and tissues of ageing mammals, a transgenic mouse model has been generated that harbours lacZ reporter genes as part of chromosomally integrated plasmids. Using this model, we determined spontaneous mutant frequencies and spectra in mouse liver and brain as a function of age. In the liver, mutant...
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