Article
Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells.
Oncogene - 23 Apr 2009
Li H, Choi Y J, Hanes M A, Marple T, Vogel H, Hasty P
Abstract excerpt
Ku70 forms a heterodimer with Ku80, called Ku that is well known for repairing DNA double-strand breaks through non-homologous end joining. As a result, deletion of either causes a very similar phenotype in mice that includes hypersensitivity to clastogens and early aging. In addition, deletion of Ku80 along with the cell cycle checkpoint protein, p53, dramatically increases the incidence of pro-B-cell lymphoma....
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