Article
Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice.
Mutation research - 15 Feb 2002
Giese Heidi, Snyder Wendy K, van Oostrom Conny, van Steeg Harry, Dollé Martijn E T, Vijg Jan
Abstract excerpt
Increased genomic instability has been found associated with cancer and aging. The p53 tumor suppressor protein is a major determinant of genomic instability as a regulator of cell cycle control and apoptosis in response to DNA damage. To investigate the rate of age-related mutation accumulation in the absence of p53, we crossed Trp53 null mice with transgenic mice harboring a lacZ mutational target gene. In the...
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