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Article

Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice

7 Feb 2008

Abstract excerpt

UNLABELLED: Chromosomal instability is a characteristic feature of hepatocellular carcinoma (HCC) but its origin and role in liver carcinogenesis are undefined. We tested whether a defect in the nonhomologous end-joining (NHEJ) DNA repair gene Ku70 was associated with chromosomal abnormalities and enhanced liver carcinogenesis. Male Ku70 NHEJ-deficient (Ku70-/-), heterozygote (Ku70 +/-), and wild-type (WT) mice...

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PMID: 18506893
DOI: 10.1002/hep.22194

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