Article
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2000
Dollé M E, Snyder W K, Gossen J A, Lohman P H, Vijg J
Abstract excerpt
Somatic mutation accumulation has been implicated as a major cause of cancer and aging. By using a transgenic mouse model with a chromosomally integrated lacZ reporter gene, mutational spectra were characterized at young and old age in two organs greatly differing in proliferative activity, i.e., the heart and small intestine. At young age the spectra were nearly identical, mainly consisting of G. C to A.T...
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