Article
Genomic instability, aging, and cellular senescence.
Annals of the New York Academy of Sciences - 1 Jun 2004
Busuttil Rita A, Dollé Martijn, Campisi Judith, Vijga Jan
Abstract excerpt
Aging can be defined in practical terms as a series of time-related processes that ultimately bring life to a close. Genomic instability has been implicated as a major causal factor in aging. Here, we describe the use of a transgenic mouse model, harboring lacZ reporter genes as part of a plasmid construct integrated at one or more chromosomal locations, to study genomic instability during aging of different...
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