Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response: a pilot study.

Pharmacological research - 1 Jan 2000

Nikisch Georg, Eap Chin B, Baumann Pierre

Abstract excerpt

The antidepressant activity of citalopram (R,S-CIT) is mainly due to its (S)-enantiomer (S-CIT). P-glycoprotein (P-gp), encoded by the ABCB1 gene, is a membrane transport protein which regulates the efflux of many drugs. Polymorphisms in the ABCB1 gene may have an impact on the expression and fun...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Citalopram

Share to Data Interpretation, Statistical

Share to Depressive Disorder, Major

Share to Pilot Projects

Share to Selective Serotonin Reuptake Inhibitors

Share to Stereoisomerism

Source

Identifiers

PMID: 18940259
DOI: 10.1016/j.phrs.2008.09.010

Genes

CIT
ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18940259-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response: a pilot study.PMID 18940259Read ↗

ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment.Semantic proximity Read ↗

ABCB1 genotyping in the treatment of depression.Semantic proximity Read ↗

The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases.Semantic proximity Read ↗

Interactions between antidepressants and P‐glycoprotein at the blood–brain barrier: clinical significance of in vitro and in vivo findingsSemantic proximity Read ↗

Antidepressants and ABCB1 gene C3435T functional polymorphism: a naturalistic study.Semantic proximity Read ↗

ABCB1 C1236T, G2677TA and C3435T Genetic Polymorphisms and Antidepressant Response Phenotypes: Results from a Portuguese Major Depressive Disorder Cohort.Semantic proximity Read ↗

MRP1 polymorphisms associated with citalopram response in patients with major depression.Semantic proximity Read ↗

The clinical application of ABCB1 genotyping in antidepressant treatment: a pilot study.Semantic proximity Read ↗

ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population.Semantic proximity Read ↗

ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder.Semantic proximity Read ↗

Effects of CYP2C19 genetic polymorphism on the steady-state concentration of citalopram in patients with major depressive disorder.Semantic proximity Read ↗

Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.