Article
ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder.
The pharmacogenomics journal - 1 Aug 2013
de Klerk O L, Nolte I M, Bet P M, Bosker F J, Snieder H, den Boer J A, Bruggeman R, Hoogendijk W J, Penninx B W
Abstract excerpt
P-glycoprotein (P-gp), an ATP-driven efflux pump in the blood-brain barrier, has a major impact on the delivery of antidepressant drugs in the brain. Genetic variants in the gene ABCB1 encoding for P-gp have inconsistently been associated with adverse effects. In order to resolve these inconsistencies, we conducted a study in a large cohort of patients with major depressive disorder with the aim to unravel the...
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