Article
ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment.
Pharmacogenetics and genomics - 1 Apr 2011
Lin Keh-Ming, Chiu Yen-Feng, Tsai I-Ju, Chen Chia-Hui, Shen Winston W, Liu Shu Chih, Lu Shao-Chun, Liu Chia-Yih, Hsiao Mei-Chun, Tang Hwa-Sheng, Liu Shen-Ing, Chang Liang-Huey, Wu Chi-Shin, Tsou Hsiao-Hui, Tsai Ming-Hsien, Chen Chun-Yu, Wang Su-Mei, Kuo Hsiang-Wei, Hsu Ya-Ting, Liu Yu-Li
Abstract excerpt
OBJECTIVE: ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) is a drug transporter protein expressed on the epithelial cells of the intestine and the endothelial cells of the blood-brain barrier. Intestinal ABCB1 actively transports drugs from the cell membrane and prevents them from entering the blood stream whereas the blood-brain barrier ABCB1 prevents drugs from entering the central nervous...
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