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Article

The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases.

Current pharmaceutical design - 1 Jan 2011

Rosenhagen Marcus C, Uhr Manfred

Abstract excerpt

Polymorphisms in the drug transporter gene ABCB1 account for differences in the clinically efficacy of the most drugs, most likely by influencing their access to the brain. The majority proportion of depressed patients, given a regular dose, do not respond properly or experience severe side effects. One explanation may be the polymorphisms in the drug transporter gene ABCB1, which account for differences in the...

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Source

Identifiers

PMID: 21827404
DOI: 10.2174/138161211797440140

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases.PMID 21827404Read ↗

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ABCB1 gene variants and antidepressant treatment outcome: A meta-analysis.Semantic proximity Read ↗

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The clinical application of ABCB1 genotyping in antidepressant treatment: a pilot study.Semantic proximity Read ↗

ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder.Semantic proximity Read ↗

[Characterisation of selected molecular mechanisms influencing pharmacokinetics and pharmacodynamics of antidepressants].Semantic proximity Read ↗

ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.Semantic proximity Read ↗

A common polymorphism in the ABCB1 gene is associated with side effects of PGP-dependent antidepressants in a large naturalistic Dutch cohort.Semantic proximity Read ↗

ABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta-Analysis Including Results from the CAN-BIND-1 Study.Semantic proximity Read ↗

Antipsychotic drug dosage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: a study from a south Indian perspective.Semantic proximity Read ↗

Single nucleotide polymorphism in the drug transporter gene ABCB1 in treatment-resistant depression: clinical practice.Semantic proximity Read ↗

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