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Article

MBD2-Mediated Transcriptional Repression of the p14ARF Tumor Suppressor Gene in Human Colon Cancer Cells

1 Jan 2008

Abstract excerpt

OBJECTIVE: The p14(ARF) and p16(INK4A) tumor suppressor genes are commonly inactivated by aberrant methylation of their promoter regions in human colon cancer. The methyl-CpG-binding domain protein MBD2 is physically associated with the methylated promoters of the p14(ARF) and p16(INK4A) genes in specific tumor cell lines. Moreover, deficiency of MBD2 strongly inhibits intestinal tumorigenesis in the Min mouse,...

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PMID: 18931530
DOI: 10.1159/000151708

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