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Article

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

eLife - 12 Mar 2014

Serra Ryan W, Fang Minggang, Park Sung Mi, Hutchinson Lloyd, Green Michael R

Abstract excerpt

Approximately 70% of KRAS-positive colorectal cancers (CRCs) have a CpG island methylator phenotype (CIMP) characterized by aberrant DNA hypermethylation and transcriptional silencing of many genes. The factors involved in, and the mechanistic basis of, CIMP is not understood. Among the CIMP genes are the tumor suppressors p14(ARF), p15(INK4B), and p16(INK4A), encoded by the INK4-ARF locus. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24623306
DOI: 10.7554/eLife.02313
PMCID: PMC3949416

Genes

KRAS
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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