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Article

Mbd4 inactivation increases C→T transition mutations and promotes gastrointestinal tumor formation

4 Nov 2002

Abstract excerpt

Mbd4 (methyl-CpG binding domain 4) is a novel mammalian repair enzyme that has been implicated biochemically in the repair of mismatched G-T residues at methylated CpG sites. In addition, the human protein has been shown to interact with the DNA mismatch repair protein MLH1. To clarify the role of Mbd4 in DNA repair in vivo and to examine the impact of Mbd4 inactivation on gastrointestinal (GI) tumorigenesis, we...

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PMID: 12417741
DOI: 10.1073/pnas.232579299

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