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Article

FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth

30 Jul 2023

Abstract excerpt

Cyclin-dependent kinase 4 (CDK4) and retinoblastoma protein (RB) are both important cell-cycle regulators that function in different scenarios. Here, we report that FERM domain-containing 8 (FRMD8) inhibits CDK4 activation and stabilizes RB, thereby causing cell-cycle arrest and inhibiting colorectal cancer (CRC) cell growth. FRMD8 interacts separately with CDK7 and CDK4, and it disrupts the interaction of CDK7...

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Identifiers

PMID: 37527040
DOI: 10.1016/j.celrep.2023.112886

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