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Article

MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers.

Oncogene - 29 May 2003

Bader Scott, Walker Marion, McQueen Heather A, Sellar Robert, Oei Elizabeth, Wopereis Suzan, Zhu Yanhua, Peter Audrey, Bird Adrian P, Harrison David J

Abstract excerpt

The genes MBD1 and MBD2 encode methyl-CpG binding proteins that suppress transcription from methylated promoters. In contrast, CGBP encodes a protein that binds promoters containing unmethylated CpG and stimulates transcription. All three are located on human chromosome 18q21, a region of frequent loss of heterozygosity in several cancers. These genes therefore represent candidate tumour suppressor genes, whose...

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Topics

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Share to Chromosomes, Human, Pair 18
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Gene Silencing

Share to In Situ Hybridization, Fluorescence

Share to Repressor Proteins

Source

Identifiers

PMID: 12776203
DOI: 10.1038/sj.onc.1206574

Genes

MBD1
MBD2
DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers.PMID 12776203Read ↗

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A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.Semantic proximity Read ↗

Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancersSemantic proximity Read ↗

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Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.Semantic proximity Read ↗

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.Semantic proximity Read ↗

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