Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells.

Cancer research - 15 Jan 2003

Lin Xiaohui, Nelson William G

Abstract excerpt

GSTP1, encoding the pi-class glutathione S-transferase, is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. We report here thathypermethylation of CpG dinucleotides at the 5' transcriptional regulatory region was sufficient to inhibit GSTP1 transcription in MCF-7 breast cancer cells and that repression of GSTP1 transcription was mediated in part by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Gene Expression Regulation, Enzymologic

Share to Gene Silencing

Share to Glutathione S-Transferase pi

Share to Glutathione Transferase

Share to Methyl-CpG-Binding Protein 2

Source

Identifiers

PMID: 12543808

Genes

GSTP1
MBD2
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells.PMID 12543808Read ↗

Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells.Semantic proximity Read ↗

Methyl-CpG-binding domain proteins: readers of the epigenome.Semantic proximity Read ↗

The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing.Semantic proximity Read ↗

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells.Semantic proximity Read ↗

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer.Semantic proximity Read ↗

Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re‐expression of GSTP1 in human prostate cancer cellsSemantic proximity Read ↗

Methyl-CpG binding domain protein 2 plays a causal role in breast cancer growth and metastasisSemantic proximity Read ↗

MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters.Semantic proximity Read ↗

MDR1 Promoter Hypermethylation in MCF-7 Human Breast Cancer Cells: Changes in Chromatin Structure Induced by Treatment with 5-Aza-CytidineSemantic proximity Read ↗

Methyl-CpG-binding domain 2: a protective role in bladder carcinoma.Semantic proximity Read ↗

DNA hypermethylation regulates the expression of members of the Mu-class glutathione <i>S</i>-transferases and glutathione peroxidases in Barrett’s adenocarcinomaSemantic proximity Read ↗

Aberrant Promoter Methylation of the <i>ABCG2</i> Gene in Renal CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.